Melatonin
Italian researcher Paolo Lissoni has published a number of studies on melatonin showing its potential to stabilize solid cancers on its own (for some time) or help improve results of chemotherapy. According to his research, lung cancer belongs to those that respond well to melatonin.
His results suggest that melatonin can possibly stabilize LC for a couple months in almost 50% patients. Melatonin needs to be high dose (20-100 mg) taken best before bedtime. Starting at 10-40 mg and increasing the dose later (when it stops working) might be a good idea as one of his studies showed that increasing the dose helps to reestablish the effect of it.
Taken with chemotherapy melatonin can increase the chance of response and lower the side effects at the same time.
Recently there have been two new studies by Lissoni which results seem to be in line with that:
https://lupinepublishers.com/research-and-reviews-journal/pdf/RRHOAJ.MS.ID.000234.pdf
Some of his previous studies are here :
https://pubmed.ncbi.nlm.nih.gov/12823608/ Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial (2003)
https://www.sciencedirect.com/science/article/abs/pii/S0369811406002513?via%3Dihub
Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms (2007)
Clinical studies with melatonin have been done almost exclusively by Lissoni's team, just like said in the summary here :
and here (where in the references you can find links to some of his many studies):
The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials
https://link.springer.com/article/10.1007%2Fs00280-012-1828-8
However, Lissoni has done numerous studies with it so it is not likely he and his team (with many people involved) would manipulate the results of the studies. Maybe there could be a little bias on his side, but still it would mean patients can potentially benefit from melatonin with nothing much to lose by trying it.
Some links to other studies of melatonin :
Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases (2021)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216835/ Melatonin as a potential anticarcinogen for non-small-cell lung cancer (2016)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412427/?fbclid=IwAR0BoB0F0_fjKruUZfZOtfPTd_uFuND9hksJrWo-rA4_b6_4glGcrPoODuE Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis
Here is a Danish study with links to numerous studies of Melatonin (none of them by Lissoni):
There is a study in lung cancer that was not conducted by Lissoni:
Daily evening melatonin prolongs survival among patients with advanced non-small-cell lung cancer
https://www.tandfonline.com/doi/full/10.1080/09291016.2021.1899485#
The greatest survival benefit occurred among the PM melatonin arm patients who reported normal quality sleep at baseline.
Melatonin-Induced Oncostasis, Mechanisms and Clinical Relevance
Sourcing
Melatonin can be purchased in capsules or in powder. A good source of cheap good quality melatonin is PureBulk:
where you can also purchase dosing spoons :